Breast Cancer: Risk Reduction and Treatments

Increase Protective Estrogen and Reduce Harmful Estrogens 

1) Maintain a high 2:16 Hydroxy-estrogen ratio. If your ratio is too lowbreast cancer risk is doubled. (Appendix 1)

2) Maintain a healthy ratio of Estriol, Estradiol and Estrone: EQ= E3 / (E2 + E1) with an optimal ratio over 1.0 (Appendix 2) 

3) Restore sufficient iodine stores in your body (Appendix 3)

4) Reduce Beta-glucuronidase: It blocks your body’s attempt to excrete harmful estrogens (Appendix 4)

5) Measure and Optimize Omega 3 Fats ratio to Omega 6 Fats (Optimal is 1:4 ratio)  (Appendix 5)

6) Measure Genetic Vulnerabilities and use Natural Modulators to “switch on” healthier genes:(Appendix 6)

Others:

1) Increase Cancer Preventative 2-Methoxyestrogen

2) Measure and Optimize methyl donators: SAMe, MethylB12,  MethylFolates and/or TrimethylGlycine (TMG)

3) Reduce Cancer Initiating 4-Hydroxy Estrogens (JNCI Jan 15, 2003)

APPENDIX I: Food and Supplements that increase 2:16 ratio:

A. Measure 2:16 ratio with a 24 hour urine test from Meridian Valley Lab, or a morning urine sample using the Estronex 2/16 Test from Metametrix Clinical Lab or equivalent lab.

1) Maintain a high 2:16 Hydroxy-estrogen ratio and reduce harmful estrogens. < 2.0 is too low, and 52 percent of a general patient population is < 2.0. If your ratio is too lowbreast cancer risk is doubled. Increase 2-OH:16OH ratio with:

1) Cruciferous vegetables contain the powerful I3C and DIM, which improve the ratio: Broccoli, cabbage, turnips, mustard greens, kale, rutabaga, cauliflower, kohlrabi, collard, and brussels sprouts.

2) Supplemental DIM (may be resistant to acid breakdown that makes I3C vulnerable.)

3) Flaxseeds: Dietary intake of 1 Tbsp of ground flaxseed per day increased the 2-OH:16-OH ratio.  (Consumption on urinary estrogen metabolites in postmenopausal women. Nutr Canc 1999;33:188-195.)

APPENDIX II: Measure your “Estrogen Quotient” and Maximize Anti-Cancer Estriol: Consider Bioidentical Hormone Therapy:

Some say an EQ of 0.4 is adequate. But if women only need an EQ of 0.4, why has breast cancer risk gone up? Not only do I think you still need an EQ of at least 1.0, as Dr. Lemon found 40 years ago, but in today’s environment, with the amount of estrogen-mimicking carcinogens increasing dramatically, it’s more important than ever to keep your level of estriol as high as possible. So I don’t see any reason why we shouldn’t still follow Dr. Lemon and shoot for an EQ of 1.0 or above.

Pictures of Estriol versus other estrogen breakdown products:

Most preparations of triple estrogens apply them in the respective percentage ratio of 80:10:10. Some pharmaceutical preparations of estrogen entirely overlook estriol; they claim it is a weak estrogen (despite the fact that woman naturally produce high levels of it). There is now a ground swell of opinion that believes that estriol has anti-cancer properties: In essence that it cancels out the carcinogenic properties of the other two estrogens.

Like other estrogens and progesterone, you should take breaks in your use of Estriol

Estrone 10 Estradiol 5 Estriol 15: Estrogen quotient 1: With the use of Lugol’s iodine (6 mg iodine/drop) 8 drops dail, estrogen quotient went up to 1.39

Estrone 3  Estradiol 15  Estriol 1: E quotient very low at 0.05: With the use of Lugol’s, it went up to 1.55

Want to make sure women are metabolizing estrogen to estriol

Do not suppress thyroid: Women with fibrocystic breast disease have a sponge for iodine

One woman needed 800 mg of iodine a day to get good quotient of 1.94

Dr Henry Lemon U of Nebraska findings:

Henry Lemon, M.D. of the University of Nebraska studied estriol and demonstrated that greater proportions of estriol are good, and perhaps even anti-carcinogenic. He found that women most likely to survive breast cancer had the largest amounts of estriol. Measure estrogen breakdown products with 24 hour urine test from Meridian Labs or equivalent test.

Women with urinary higher estriol had a better chance of surviving long-term breast cancer

Estriol/ estrone and estradiol: The higher the quotient, the more likely to survive

Giving a high dose (15 mg) of estriol to women with metastatic breast CA to bone resulted in 40% remission

Rural Japan, higher estriol, less likely to have breast CA

Daughter’s of breast ca have lower estriol

Estriol lowers the risk of diabetes

2 mg estriol improved bone density

Estriol helps NO production in endothelium at a dose of 2 mg

In Japan: Safety studies found that Estriol 2 mg does not induce endometrial proliferation

For Esnatri cream (2mg per ml):

1 ml of the cream delivers 2 mg of estrogens (in the ratio 90% estriol, 7% estradiol and 3% estrone).
The cream is applied topically. Women in menopause might take 1.5mg to 3.5mg (average 2mg) daily, from day 1 of the menstrual cycle to day 25, stop and then repeat the following month. The cream can be applied topically using the fingertips to the neck, upper chest, and breasts, behind the knees or inner thighs. The site should be rotated daily.

Ask “when you were having pretty regular cycles and bleeding for the same length of time, how many days did you have menstrual bleeding? Oh, it was five days — then I want you to try to leave off your hormone replacement for five days. Give your body the same break. Oh, it was only three days? Well, fine then leave your hormone replacement off for three days. Duplicate exactly what happens in you, because not only are we trying to mimic nature, we’re trying to mimic individual nature.”

Then the last part is, “Do you know when your ovulation happened?” If you had bleeding for four days then start that estrogen on the fifth day and then if you know your ovulation was on day No. 12, then start the progesterone on the 12th day and count that out to how many days your usual cycle went. Let’s say it was 28 days, and you count that out to day No. 27 and then quit and then 28 should become day No. 1 again. If it doesn’t happen then you may want to quit a day or so earlier.”

The whole point is trying to duplicate whatever a woman’s own body did.

Appendix 3:  Restore sufficient iodine stores in your body

Max Gerson worked his entire career on iodine metabolism: Healthy levels of iodine help prevent breast cancer by reducing 16-OH and increasing estriol levels. Population studies show dramatic deficiencies in human iodine stores, insufficient iodine in most table salt, and blockade of normal iodine function with toxins such as perchlorate.

Since estradiol and estrone can metabolize to estriol only through 16a-hydroxyestrone, it appears that iodine somehow greatly stimulated this pathway.

Dr. John Myers found iodine therapy to be very effective for fibrocystic breast disease (caused by too much estrogen). He performed estrogen testing, and in the majority of these women the quantity of estriol greatly increased, and the total quantity of estrone and estradiol (combined) decreased following the iodine treatment.

IODINE:

If use iodine need to check thyroid and can get allergy

Estriol has to go through dangerous 16 alpha OH E1  UNLESS give iodine

Get rid of fibrocystic breast disease with intravaginal swab of iodine

And mag citrate IV

Appendix 4: The problem with “Beta-glucuronidase:”

Beta-glucuronidase stops the body’s ability to eliminate harmful estrogens and other toxins as they flow through the gall bladder and liver and into the intestines to be excreted.

Once estrogen is processed in phase 2, it is excreted in the bile and urine. The estrogen metabolite-containing bile passes into the intestines where there is an enzyme in the body called beta-glucuronidase.

Beta-glucuronidase hinders the excretion of estrogen metabolites because it breaks the bond between glucuronide and the estrogen metabolite to which it is bound to for elimination.

Beta-glucuronidase blocks your body’s attempt to excrete these metabolites, and instead, these metabolites are re-absorbed into the body, where they can wreak more havoc with excessive and/or prolonged stimulation of the estrogen receptor. Beta-glucuronidase also increases the carcinogenicity of some compounds. Beta-glucuronidase is stimulated by eating meat and animal fat and is suppressed by consuming fiber.

THE SOLUTION:

Doctors and patients use a substance to reduce beta-glucuronidase activity. With this substance, estrogens, estrogen metabolites and other toxins stay bound to glucuronide so that they can be eliminated in the feces.  The substance is a supplement called calcium D-glucarate, which not only inhibits beta-glucuronidase, but also increases the activity of the glucuronidation phase 2 pathway, with the net effect being that more estrogens, metabolites, and other toxins are eliminated from the body.

Calcium D-glucarate has been found in animal models to lower estradiol levels and inhibit the initiation, promotion, and progression of cancer. In other studies, after exposure to carcinogens, calcium D-glucarate was found to decrease breast cancer formation. It is important to understand that it is the glucarate, and not the calcium, responsible for these effects.

Appendix 5:  Measure and Optimize Omega 3 Fats ratio to Omega 6 Fats (Optimal is 1:4 ratio)  (Appendix 5)

A. Omega 3 increases 2-OH (Telang NT, Bradlow HL, Osborne MP. Molecular and endocrine biomarkers in non-involved breast: relevance to cancer chemoprevention. J Cell Biochem Suppl 1992;16G:161-169.)  

B. The Omega 3 DHA causes decreased binding of estradiol to the estrogen receptor. (Borras M, Leclercq G. Modulatory effect of nonesterified fatty acids on structure and binding characteristics of estrogen receptor from MCF-7 human breast cancer cells. J Recept Res 1992;12:463-484.)

C. Omega 6 decreases 2-OH (Davis DL, Bradlow HL, Wolff M, et al. Medical hypothesis: xenoestrogens as preventable causes of breast cancer. Environ Health Perspect 1993;101:372-377.)

D. Omega 6 increases 16-OH. (Bartsch H, Nair J. Owen RW. Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers. Carcinogenesis 1999;20:2209-2218.)

Appendix 6:  Measure Genetic Vulnerabilities and use Natural Modulators to “switch on” healthier genes:(Appendix 6)

The CYP1A1 enzyme is helpful as it increases 2-Hydroxyestrogens (and therefore decreases 16-Hydroxyestrogens). If genetically deficient, induce this enzyme with supplements.

Too much of the CYP1B1 enzyme is undesirable, as it creates 16- Hydroxyestrogens. This enzyme is not only inducible by diet, but by toxins, carcinogens and pesticides. (Fishman J, Osborne MP, Telang NT. The role of estrogen in mammary carcinogenesis. Ann N Y Acad Sci 1995;768:91-100.)

The regular use of detoxification of chemicals with sauna, binders and other techniques will help to rid your fat cells of PCB’s and other xenobiotics that increase the CYP1B1 enzyme and cause other effects in cells.

Tamoxifen, Flavones (chrysin, baicalein & galangin), flavanones (naringenin) and isoflavones (genistein, biochanin A) inhibit the activity of aromatase (CYP19), thus decreasing estrogen biosynthesis and producing antiestrogenic effects, important in breast and prostate cancers.

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