Cytokine Inhibitors (Anti-Inflammatories by Category)

Cytokine Inhibitors

Anti-oxidants

Vitamin C Vlahopoulos S, et.al. Blood 1999;94:1878-89

Vitamin E Wu D, et.al. Atherosclerosis. 1999; 7:297-307.

N-acetyl-cysteine Gosset P, et.al. Eur Respir J 1999;14:98-105

Alpha-lipoic acid Suzuki YJ, et.al. Biochem Biophys Res Commun 1992;189:1709-15

Coenzyme Q10 Hodges S, et.al. Biofactors 1999;9:365-70

Diet and Nutritional Supplements

Asparagus Kim H, et al. Int J Immunopharmacol 1998;20(4-5):153-62 cochinchinensis Dirks J, et.al.

Prostaglandins Leukotriene Essent Fatty Acids 1998;59:273-7

Gamma linoleic acid Venkatraman JT andChu WC. J Am Coll Nutr 1999;18:602-13

Omega-3 lipids James MJ, et al. Am J Clin Nutr 2000;71(1 Suppl):343S-8S

Fish oil James MJ, et al. Am J Clin Nutr 2000;71(1 Suppl):343S-8S Flaxseed oil Engelberts I, et.al. Br J Nutr 1993;69:159-67

Palm oil Andoh A, et.al. JPEN J Parenter Enteral Nutr 1999;23(5 Suppl):S70-3

Fiber Andoh A et al. Clin Exp Immunol 1999;118:23-9

Butyrate Ha CL, et.al. J Food Prot 1999;62:181-8

Yogurt Spittler A, et al. FASEB J 1999 ;13:563-71

L-Glycine Haberstroh U, et al. J Am Soc Nephrol 1998 ;9:203-10.

L-Arginine Connell P, et al. J Am Coll Nutr 1997 ;16:411-7

Zinc Hasko G, et al. J Immunol 2000;164:1013-9

Inosine Kontny E, et al. Arthritis Rheum 1999;42:2552-60

Taurine chloramine Watson WH, et al. Biochem J 1999;342 ( Pt 1):21-5

S-adenosylmethionine (SAMe) Araghi-Niknam M, et al. Proc Soc Exp Biol Med 1997 ;216:386-91 

Herbal Medicines

Capsaicin Yu R, et al. Int J Vitam Nutr Res 1998;68:114-9

Curcumin Jobin C, et al.. J Immunol 1999;163:3474-83

Epigallocatechin Yang F, et al. J Nutr 1998;128:2334-40

Ginkgo biloba Breton JJ, et al. J Pharmacol Exp Ther 1997;282:459-66 Hymenialdisine Wang LM,et al.. J Pharm Pharmacol 1997;49:102-4

Quercetin Murase T, et al. Arterioscler Thromb Vasc Biol 1999;19:1412-20 

Gallic acid esters (red wine) Lyss G, et al. J Biol Chem 1998 11;273:33508-16

Sesquiterpene Riehemann K, et al. FEBS Lett 1999; 8;442:89-94

lactone helenalin Surh Y. Mutat Res 1999;428:305-27

Silymarin

Urtica dioica

Zingiberaceae

Anti-leukotriene medications

Montelukast Denizot Y, et al. Cytokine 1999;11:606-10

Zileuton Aoki Y, et al. Am J Physiol 1998;274:L1030-9

Over the Counter anti-ulcer medications

Sulglycotide Slomiany BL, Piotrowski J, Slomiany A.

Rebamipide Aihara M, et al.. Dig Dis Sci 1998;43(9 Suppl):174S-180S

Polaprezinc Shimada T, et al.. J Pharmacol Exp Ther 1999;291:345-52

Over the Counter anti-rheumatic medications

Aspirin Shi X, et al. Mol Cell Biochem 1999;199:93-102.

Ibuprofen Stuhlmeier KM, et al. Biochem Pharmacol 1999 1;57:313-20

Sodium salicylate Lemay S, et al. Clin Diagn Lab Immunol 1999;6:567-72

Nimesulide Azab A, et al. J. Life Sci 1998;63: 323-7

Diclofenac Henrotin YE, et al. Clin Exp Rheumatol 1999;17:151-60

Prescription anti-rheumatic drugs*

Chloroquine Zhu X, et al.. Immunology 1993;80:122-6

Sulfasalazine Deleuran B, et al. Cytokine 1992;4:403-9

D-penicillamine Deleuran B, et al. Cytokine 1992;4:403-9

Gold Yoshida S, et al. Int Immunol 1999;11:151-8

Glucocorticoids Bourke E, and Moynagh PN. J Immunol 1999;163:2113-9.

Methotrexate Boiardi L, et al. Clin Exp Rheumatol 1999;17:419-25

Bucillamine Matsuno H, et al.. Int J Immunopharmacol 1998;20:295-304

Quinine Maruyama N, et al. Am J Respir Cell Mol Biol 1994;10:514-20

Quinacrine Bondeson J, and Sundler R. Gen Pharmacol 1998;30:357-66

Thalidomide Dunzendorfer S, et al. Immunopharmacology 1999;43:59-64

Antibiotics that suppress chemokines*

Clarithromycin Matsuoka N, et al. Clin Exp Immunol 1996;104:501-8

Roxithromycin Nonaka M, et al. Acta Otolaryngol Suppl 1998;539:71-5

Erythromycin Takizawa H, et al. J. Am J Respir Crit Care Med 1997;156:266-71

Doxycycline Attur MG, et al. J Immunol 1999 15;162:3160-7

Minocycline Attur MG, et al. J Immunol 1999 15;162:3160-7

Other Drugs that can suppress chemokines*

ACE Inhibitors+ Gullestad L, et al. J Am Coll Cardiol 1999;34:2061-7

HMG-CoA reductase inhibitors Ortego M, et al. J. Atherosclerosis 1999;147:253-61 Lane TE,et al. J Neurovirol 1999;5:48-54

Nitric oxide synthase inhibitors Rodler S, et al. J Mol Cell Cardiol 1995;27:2295-302

Ca(2+)-channel blockers Kunkel SL, et al. J Biol Chem 1988 15;263:5380-4 Zidek Z, et al. Eur J Pharmacol 1999 2;376:91-100 PGE(2) including agents Martelius T, et al. Transplantation 1999 15;68:1753-61

Nucloside analogue Neuner P, et al. Immunology 1994 ;83:262-7

Desferrioxamine Yuengsrigul A, et al. Ann Allergy Asthma Immunol 1999;83:559-66

Pentoxifylline Rittenhouse PA, and Redei E. Endocrinology 1997 ;138:1434-9

Furosemide Pero RW, et al. Mol Cell Biochem 1999;193:119-25

Thyroxine Roubenoff R,et al. Arthritis Rheum 1995;38:105-9

Vitamin B3 Buccellato FR, et al.. FASEB J 1999;13:297-304

Vitamin B6 Harant H, et al.. Eur J Biochem 1997 15;250:63-71

Vitamin B12 Vassiliadou N, et al. J Immunol 1999;15;162:7510-8

Vitamin D Inadera H, et al. Endocrinology 2000;141:50-9

Progesterone Saitoh O, et al. J Gastroenterol Hepatol 1998;13:1212-7

Estrogens Kawasaki T, et al. Anesth Analg 1999;89:665-9

Bile acids Grimm MC, et al. Ann N Y Acad Sci 1998 1;840:9-20

Ketamine Bessler H, et al. Biomed Pharmacother 1999;53:141-5

Morphine Muller T, J Neural Transm Suppl 1998;52:321-8.

Levodopa Maes M, et al. Neuropsychopharmacology 1999;20:370-9

Selegiline Maes M, et al. Neuropsychopharmacology 1999;20:370-9

Sertraline Moots RJ, et al. Ann Rheumatic Dis 1999;58:585-7

Trazadone

Haloperidol

Chemokine and chemokine receptor blocking agents

Heparin* Ramdin L, et al. Clin Exp Allergy 1998;28:616-24

Chondroitin Kuschert GS et al. Biochemistry 1999;38:12959-68

Mannans Mbemba E, et al. Virology 1999;265:354-64

Peptide T Redwine LS, et al. Clin Immunol 1999;93:124-31

+ ACE Angiotension converting enzyme

# Cholesterol lowering

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