Anti-Aging: Increase Brain Blood Flow

Brain circulation (also called cerebral blood flow or blood flow to the brain) is very important for all aspects of brain function. Your brain depends critically on oxygen, glucose, and other nutrients that the blood brings.

The lack of oxygen to the brain (hypoxia) also increases oxidative stress in the brain, which kills brain cells and causes neurodegenerative diseases such as Alzheimer’s.

Ensuring that you have good blood flow to the brain is critical for health and recovery from any chronic disease.

Original capil glial neuron

The brain is the most important organ to receive the blood supply. Although it’s only 2% of your body weight, it consumes 50% of glucose and 20% of the oxygen that is available in the body [R].

In addition, the blood also removes wastes from the brain. Lack of oxygen for merely minutes will start to kill brain cells.

However, during most of the days, when we are upright, the brain is the highest part of the body with the smallest blood vessels that are furthest from the heart. This makes the brain a difficult organ to deliver blood to.

Too little blood flow results in a lack of glucose and oxygen needed to keep neurons metabolically active, a condition known as ischemia. Too much blood flow results in increased intracranial pressure, which causes severe neurological damage in extreme cases.

Therefore, the body has several checks and balances to ensure that the brain receives sufficient blood flow and oxygen [R].

Adults with normal blood pressure get about 50 ml of blood to 100 g of brain tissue per minute, which provides oxygen pressure to the brain at between 60 – 160 mmHg [R].

If the oxygen pressure to the brain falls outside of this range, the brain loses its ability to maintain constant blood flow, so the blood flow strictly depends on the pressure within the arteries (mean arterial pressure) [R].

Causes of Poor Brain Circulation

1) Low or High Blood Pressure Reduces Brain Circulation

Many clients have very low blood pressure due to low vasopressin (ADH) levels, so low blood flow to the brain is a major concern.

Low blood pressure has been related to risk of brain atrophy (loss of brain tissue). In a study examining patients with hardening of the arteries, not all patients with lower blood pressure had low blood flow to the brain. However, those with lower blood pressure and less blood flow to the brain were more likely to have brain atrophy [R].

Note: In this study, low blood pressure considered only systolic (the higher number) below 120.

In some people with hypertension, the hypertension is caused by constriction of the blood vessels (vasoconstriction), which also reduces blood flow to the brain. Hormones like vasopressin and angiotensin II constrict the blood vessels and cause these effects [R].

Conversely, drugs that reduce the functions of these hormones, such as angiotensin II inhibitors (many blood pressure drugs) increase blood flow to the brain [R].

High histamine or mast cell activation also causes low blood pressure because histamine is a vasodilator [R].

It is therefore important to maintain healthy blood pressure in order to have good brain circulation.

2) Poor Circulation

Factors that cause poor circulation include:

  • Inflammation and infections, such as bacterial meningitis [R]
  • Low thyroid is associated with lower brain circulation, which may contribute to depression among these patients [R]
  • Low nitric oxide, although too much can be neurotoxic [R]
  • Poor blood vessel health, such as from hardening of the arteries, and high blood sugar

3) Oxidative Stress

Oxidative stress damages the blood vessels. In turn, low brain blood flow also increases oxidative damage in the brain.

When oxidative species attack red blood cells and other components in the blood vessel, these damaged components can clump up and make the blood more viscous. This can impair blood flow [R].

Oxidative stress also results in poor blood vessel health and stiffening of the blood vessels, which results in poor circulation.

Angiotensin II activates NADPH oxidase, which generates ROS in the brain (celebral) arteries [R].

4) Stress

Chronic stress and stress from provoking a traumatic experience reduces blood flow to the brain, but increases blood flow to the amygdala (the fear response center) [RR].

Acute mental stress, however, increases blood flow to the brain. Levels of blood flow to the brain correlate with the increased heart rate and cortisol levels [R].

Health Problems Linked to Poor Brain Circulation

1) Brain Fog or Poor Cognitive Function

Brain circulation is associated with energy production in the brain and plays an important role in preserving cognitive functions [RR].

Therefore, increasing brain circulation in certain areas of the brain may improve cognitive deficits [R].

In the Rotterdam Study, a large longitudinal study designed to assess the factors related to dementia and cognitive decline, researchers found that in 1,716 subjects without dementia, increased probability of cognitive decline was related to decreased brain blood flow [R].

Adequate blood flow is crucial to normal cognitive function and preserving circulation in the brain may be important in slowing down and even preventing cognitive decline later in life.

Poor Brain Circulation May Cause Neurodegenerative Diseases

Brain circulation has also been linked to various neurodegenerative diseases and mental disorders.

2) Parkinson’s Disease

Parkinson’s disease patients with dementia display decreased blood flow in certain areas of the brain in comparison to controls [R].

3) Alzheimer’s Disease

Reduced blood flow in key brain regions is one of the earliest signs of Alzheimer’s disease and therapy that increases blood flow to the brain shows some benefits to Alzheimer’s patients [R].

Poor Brain Circulation and Mental Health

4) Depression

Decreased blood flow in the select brain regions has also been shown to occur in patients with late-life depression [R].

5) PTSD

Source: http://jamanetwork.com/journals/jamapsychiatry/fullarticle/481961

Generally, provoking the traumatic experiences in PTSD patients result in increased blood flow to the amygdala (brain region associated with fear conditioning) and decreased blood flow to other regions of the brain [RR].

6) OCD and Anxiety Disorder

People with anxiety disorders, OCD, agoraphobia, and PTSD have significantly less brain blood flow than healthy people [R].

Reduced Brain Circulation Causes Fatigue

7) Exercise-Induced Fatigue and General Fatigue

It is normal to become fatigued after exercise or physical exertion. Part of the fatigue is explained by the reduction of blood flow to the brain.

During exercise, increased breathing (hyperventilation) reduced the amount of carbon dioxide in the arteries. This restricts the blood flow to the brain. The reduction of available oxygen to the brain contributes to fatigue [R].

Hypoxia induces an increase in nitric oxide and adenosine in the brain [R].

The increased adenosine levels in the brain may cause drowsiness.

8) Chronic Fatigue Syndrome

Chronic fatigue syndrome patients have less blood flow to the brain than healthy people [R].

9) Traumatic Brain Injuries

Lack of oxygen in the brain tissue (ischemia) is observed in ~30% of people with traumatic brain injuries [R].

In addition, the severity of the injuries correlates with the reduction in blood flow to the brain [RR].

Lifestyle Changes That Increase Brain Circulation

1) Moderate Intensity Exercise Increases Brain Circulation

Brain blood flow has been shown to increase during easy to moderate exercise [R].

Conversely, high-intensity exercise actually decreases blood flow to the brain, as blood is redistributed throughout the body to reduce body temperature.

2) Cold Exposure to the Hands, Feet, or Face

Cold water increases circulation in the brain.

Research shows that immersing one foot or hand in cold water for a few minutes increased blood pressure and brain blood flow speed [RR].

Submerging the face in cold water triggers a reflex and causes the heart rate to decrease, non-vital blood vessels to constrict, blood vessels in the heart and brain to dilate, and blood pressure to increase [R].

3) Sun Exposure Increases Brain Circulation

Sun exposure increases nitric oxide, which dilates the blood vessels and lowers the blood pressure [R].

This might explain why sun exposure improves alertness and brain function.

4) Whole Body Vibration Increases Brain Circulation

Whole body vibration therapy increases blood flow throughout the body in humans [R].

In rats, prolonged whole body vibration therapy increased blood flow to the brain [R].

5) Inversion Therapy Increases Brain Circulation

By gravity, inversion therapy should increase blood flow to the brain.

6) Caffeine Restriction Improves Brain Circulation

It is well-documented that caffeine, both chronic and acute, causes vessels in the brain to constrict by blocking adenosine receptors, consequently reducing resting blood flow in the brain [RR].

While the brain does compensate for this by increasing adenosine receptors during daily caffeine use, research shows this compensation does not completely counteract the decrease in blood flow [R].

To mitigate the effects of caffeine on brain circulation, it is advisable to take periodic breaks from caffeine consumption.

Supplements That Directly Increase Brain Circulation

7) Ginkgo Biloba Increases Brain Circulation

The leaves of the Ginkgo biloba tree have been shown to increase blood flow in specific areas of the brain as well as overall brain blood flow [R].

A systematic review and meta-analysis found that the herb improved cognitive function and daily living activities in dementia patients [R].

8) Vinpocetine Increases Brain Circulation

Vinpocetine plays an important role in the management of neurological diseases. It selectively increases brain blood flow, energy production, and may improve the cognitive function [R].

Vinpocetine increases blood flow in the brain by thinning out blood and preventing blood from clotting [RR].

9) Ibudilast Increases Brain Circulation

Ibudilast is commonly used in Japan to treat patients with stroke. It improves brain blood flow by dilating blood vessels and prevents platelet aggregation by inhibiting PDE4 [R].

Ibudilast increases brain blood flow in patients suffering from stroke and chronic brain diseases [RR].

10) Citrulline Increases Brain Circulation

Citrulline, a precursor of arginine, increases nitric oxide concentrations in the blood and restores damaged blood vessels.

Treatment with citrulline prevents the decrease in brain circulation, death of brain cells, and capillary loss following blood supply impairment to the brain. Citrulline improves cognitive dysfunction and memory in rats with brain damage [RR].

11) Carnitine Increases Brain Circulation

Carnitine is a natural compound found in many animals, plants, and organisms.

Acetyl-L-carnitine, which is derived from carnitine, increases brain blood flow in patients with stroke [RR].

Moreover, acetyl-L-carnitine improves energy status, decreases oxidative stress, and prevents cell death in brain injuries [R].

12) Ginseng Increases Brain Circulation

Ginseng has antioxidant and anti-inflammatory properties and protects neurons from damage [R].

Its extract increases brain blood flow, capillary densities, and production of blood vessels. Ginseng helps brain injuries caused by insufficient blood supply to the brain [RR].

13) Resveratrol Improves Brain Circulation

Resveratrol increases blood supply to the brain and improves cognitive function and mood. It decreases the risk of developing dementia in postmenopausal women and other at-risk populations [RRR].

Resveratrol works by dilating blood vessels in the brain, thus increasing brain circulation [R].

14) NAC (N-Acetyl Cysteine) Increases Brain Circulation

In rats, NAC opens up blockages caused by stroke in arteries and blood vessels [R].

NAC is an antioxidant that increases brain blood flow and oxygen delivery, combats oxidative stress, prevents cell death, and minimizes the size of brain injuries in humans and animals [RR].

15) Nitrate-Rich Foods Increase Brain Circulation

Nitrate-rich foods include beets, leafy greens (like spinach and arugula), celery, and carrots.

Dietary nitrates are converted into nitric oxide in the body. Research shows that nitrates derived from vegetables increase brain blood flow in response to cognitively-demanding tasks and improve cognitive performance [R].

In a pilot study, nitrate-rich beet juice increased nitric oxide concentration in the blood, decreased blood pressure, and improved cognitive functions [R].

16) Bacopa Increases Blood Flow to the Brain

In rats, bacopa increases brain blood flow independent of blood pressure [R].

Supplements That Protect the Brain from Suboptimal Circulation

17) Ginger Protects the Brain

Zingerone, an antioxidant of ginger, prevents the death of neurons and reduces oxidative stress in rats with brain damage caused by insufficient blood supply [R].

18) Anthocyanins Protects Brain Circulation

Anthocyanins protect against brain disorders that result from a reduction in blood flow to the brain.

They reduce neuronal damage caused by inadequate blood supply in rats. Anthocyanins prevent the production of proteins that trigger cell death and suppress tumors (p-JNK and p53 transmission pathways) [R].

An extract containing anthocyanins protects brain circulation and blood vessel function following brain damage [R].

19) Astragalus Improves Brain Function

Astragalus is commonly used in traditional Chinese medicine. In a rat study, Astragalus prevented brain cell death, reduced the size of brain injuries, and improved brain function in brain injuries caused by reduced circulation [R].

Brain injuries caused by insufficient blood supply often cause inflammation and swelling. One of the major components of Astragalus alleviates these symptoms through anti-inflammatory effects [R].

20) Phosphatidylcholine Prevents Brain Damage

Phosphatidylcholines are the main component of all cell membranes. Good sources of phosphatidylcholine are eggs, dairy, soybeans, red meat, whole grains, and cruciferous vegetables (like arugula and brussel sprouts).

Disruption of brain circulation is associated with decreased levels of phosphatidylcholine in patients with stroke [RR].

Lecithin, a collection of phospholipids that usually include phosphatidylcholine, may protect neurons from damage caused by lack of blood flow in the brain [R].

Diseases That Adversely Affect Brain Circulation

Cerebrovascular diseases affect the vessels of the brain that result from insufficient blood flow to brain cells, and include:

  • Stroke: An abrupt interruption of constant blood flow to the brain, causing loss of neurological function. A stroke can be caused by a blockage in a blood vessel (ischemic) or bleeding in the brain (hemorrhagic)
  • Stenosis: Abnormal narrowing of the blood vessels, usually caused by hardening of the arteries
  • Aneurysm: Bulge in the wall of an artery that pools with blood

Cerebrovascular diseases have many different causes, including hardening of the arteries, lodging of a blood clot or foreign material in the blood vessels (embolism), or high blood pressure. Therefore, any lifestyle or dietary intervention that improves these factors improves blood flow in the brain.

Limitations

Increasing brain circulation may not guarantee that cognitive functions such as memory or attention will be improved, despite correlations between brain circulation and cognitive function.

FDA Compliance

The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition.

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