Decrease p38 and increase NAD+ in and out of the cell: More NAD+ is like having more energy, and it declines with aging:
Unfortunately, CD38 is a very inefficient enzyme and consumes as many as 100 NADs for every one cyclic-ADP-ribose that it makes. For this reason, some experts on CD38 feel that the #1 function of CD38 is to regulate cellular NAD levels.
A strong argument for this theory is the recent discovery that CD38 is found inside the cell as well, bound to membranes on the inner portion of the cell nucleus. Here it could deplete nuclear NAD.
Interestingly, the apple skin-derived flavanoid, apigenin, is a powerful inhibitor of CD38. Parsely is the food that has the most concentrated levels of apigenin. Treatment of cell cultures with apigenin increased NAD levels in the cells, reduced global acetylation of proteins, and reduced the acetylation of p53 and RelA-p65 subunits of NF-kB.
Here is a list of the foods with the most concentrations of apigenin:
|13506.20 mg||100 grams||Apigenin||Spices, parsley, dried|
|302.00 mg||100 grams||Apigenin||Parsley, raw|
|8.71 mg||100 grams||Apigenin||Peppermint, fresh|
|5.00 mg||100 grams||Apigenin||Thyme, fresh|
|4.61 mg||100 grams||Apigenin||Celery, raw|
|3.85 mg||100 grams||Apigenin||Rutabagas, raw|
|2.41 mg||100 grams||Apigenin||Celeriac, raw|