Cellular energy comes from the mitochondria: Increase their output:
1. Stimulate Mitochondrial Repair, Building & Renewal Genes:
(Mitochondria have their own set of separate genes)
A. Increase the “master regulator” of building new & healthy mitochondria: PGC-1a
***Take PQQ (Pyrroloquinoline Quinone)
***Use any of the supplements below to increase NO, SIRT1, or AMPK and thereby increase PGC-1a
***Take Quercetin to decrease breakdown of PGC-1a
(Courtesy of Zymogen)
B. Stimulate “Autophagy”
Autophagy is the the cell’s trash disposal system to digest large, “baggy,” dysfunctioning mitochondria (Also called “Mitophagy.”) This process replaces large, “baggy,” inefficient mitochondria–that have deteriorated from microbial, toxin, inflammation damage, and aging. Use:
2. Stimulate Nrf2:
This genetic “Antioxidant Response Element” can be “switched on” to produce powerful anti-oxidant enzymes: Each enzyme eliminates free radicals at a rate of one million per second. No antioxidant supplement can approach these powerful effects.
Nrf2 Produces glutathione-containing antioxidants GSH, GST’s, GPx’s–as well as Catalase and others.
Natural substances that stimulate Nrf2 to increase gene production of the ARE (antioxidant response element) include:
***Tumeric (with its active ingredient Curcurmin)
***Protandim–A supplement that combines many herbs that stimulate Nrf2: Clinically demonstrated to protect the cell from free radical damage as it can decrease the level of “lipid peroxides” over time. There are other products combining Nrf2 stimulators as well.
3. RESTORE CELL ENERGY IN THE MITOCHONDRIA:
A. Increase cell energy by increasing NAD+ in the cell with Nicotinamide Riboside: More NAD+ in the cell means not only more energy can be produced for your functioning, but also more energy for the cell to dispose of inefficient mitochondria and build smaller, more efficient mitochondria–Another way of contributing to mitochondrial mitophagy and biogenesis.
B. Increase cell energy by decreasing the activity of p38. Reducing this energy-expensive process allows more energy for these other repair processes. Interestingly, the food-derived flavanoid, apigenin, is a powerful inhibitor of CD38. Treatment of cell cultures with apigenin increased NAD levels in the cells..
Reference: 2012 Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.
Here is a list of the foods with the highest concentration of apigenin:
|13506.20 mg||100 grams||Apigenin||Spices, parsley, dried|
|302.00 mg||100 grams||Apigenin||Parsley, raw|
|8.71 mg||100 grams||Apigenin||Peppermint, fresh|
|5.00 mg||100 grams||Apigenin||Thyme, fresh|
|4.61 mg||100 grams||Apigenin||Celery, raw|
|3.85 mg||100 grams||Apigenin||Rutabagas, raw|
|2.41 mg||100 grams||Apigenin||Celeriac, raw|
C. Increase Cell Energy by providing the supplements that improve the function of the mitochondria.
A. Supplement with CoEnzyme Q10, a necessary part of the heart of the mitochondria-the Electron Transport Chain bellow:
B. Increase cell energy with any of the following other supplements which help the functioning of the mitochondria: Acetyl-L-Carnitine, Resveratrol, Membrane- Phospholipids, Creatine, Alpha-Lipoic Acid, Green Tea, Glucosamine, Omega-3-Fatty Acids, & N-Acetyl-Cysteine
C. Improve Mitochondrial functioning by Reducing Mitochondrial Free Radicals (ROS & RNS) Damage:
A. Take 3-5 mg of Melatonin at bedtime. As you see below, Melatonin has multiple beneficial effects on your mitochondrial functioning.
Melatonin permeates cell membranes and scavenges the ROS (“free radicals”) in the cell cytoplasm, mitochondria and nucleus. In the cytoplasm, melatonin maintains GSH homeostasis. Melatonin also regulates the expression of anti-oxidant enzymes, such as glutathione peroxidase (GPx), glutathione reductase (GRd) and superoxide dismutase (SOD), and downregulates pro-oxidant enzymes, such as the NOSs, particularly the iNOS. Melatonin is accumulated in mitochondria at high concentrations, where it scavenges ROS and RNS. Melatonin also protects cardiolipin from oxidation and prevents respiratory chain complexes, as well as mtDNA from free radical attack, thus ultimately protecting the membrane permeability transition (mPT) pore, thus preventing cell apoptosis.
B. Carnisine 1.5-2.0 grams/day
C. Supplement with Glutathione–The master protector
Take EXTRA Vitamin C and Pycnogenol to increase your free radical defense.
Learn to separate activities that produce large amounts of free radicals. For instance, separate eating from exercise by over one hour
Start your meal with healthy nutrients to promote Liver & GI function. See Detox Liver
Finally, See list below to choose high “ORAC” foods in your diet–graded by how well they neutralize the free radicals from a meal–Especially in high protein or high fat meals. Or use high ORAC supplements such as Optiberry or Purple defense.
|Rank||Food||Serving Size||Total Antioxidant
|1||Small Red Bean||1/2 cup
|2||Wild blueberry||1 cup||13427|
|3||Red kidney bean||1/2 cup
|4||Pinto bean||1/2 cup||11864|
|5||Blueberry||1 cup cult-
|7||Artichoke hearts||1 cup
|12||Red Delicious apple||1||5900|
|15||Sweet cherry||1 cup||4873|
|17||Russet potato||1 cooked||4649|
|18||Black bean||1/2 cup
To give you an idea of how ORAC-powerful the spices can be, look at this 2006 list from
Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States
|Oregano leaf, dried||40.299|
|Basil leaf, dried||12.307|
|Mustard seed, yellow, ground||10.527|
|Chocolate, baking, unsweetened||8.876|
|Pudding mix, chocolate, cook-and-serve||3.026|
|Power bar, chocolate flavor2||2.757|
|Cabbage, red, cooked||2.153|
|Barley malt syrup, organic||2.121|
|Peppers, red, cooked||1.640|
|Chocolate cookies with vanilla creme filling||1.604|
|Cocoa Krispies cereal3||1.558|
|Chocolate chip cookies||1.524|
|Mustard, yellow, prepared||1.501|
|Flaxseed, ground or milled||1.125|
|Rice and corn cereals||1.121|
|Toasty peanut crackers||1.101|