CFIDS: Increase Cell Energy

Cellular energy comes from the mitochondria: Increase their output:

Mitochondria in Cell

1. Stimulate Mitochondrial Repair, Building & Renewal Genes:

(Mitochondria have their own set of separate genes)

     A. Increase the “master regulator” of building new & healthy mitochondria:   PGC-1a  

***Exercise 

***Take PQQ (Pyrroloquinoline Quinone) 

***Use any of the supplements below to increase NO, SIRT1, or AMPK and thereby increase PGC-1a

***Take Quercetin to decrease breakdown of PGC-1a   

Mitochondrial Biogenesis Nutrients

(Courtesy of Zymogen)

     B. Stimulate “Autophagy”

Autophagy is the the cell’s trash disposal system to digest large, “baggy,” dysfunctioning mitochondria (Also called “Mitophagy.”) This process replaces large, “baggy,” inefficient mitochondria–that have deteriorated from microbial, toxin, inflammation damage, and aging. Use:

***Dietary Restriction

***Resveratrol,  and/or

***Metformin

2. Stimulate Nrf2:

This genetic “Antioxidant Response Element” can be “switched on” to produce powerful anti-oxidant enzymes: Each enzyme eliminates free radicals at a rate of one million per second. No antioxidant supplement can approach these powerful effects.

Nrf2

Nrf2 Produces glutathione-containing antioxidants GSH, GST’s, GPx’s–as well as Catalase and others. 

Natural substances that stimulate Nrf2 to increase gene production of the ARE (antioxidant response element) include:

***Tumeric (with its active ingredient Curcurmin)

***Cruciferous Vegetables

***Enerolactones

***Resveratrol

***Wasabe

***Protandim–A supplement that combines many herbs that stimulate Nrf2: Clinically demonstrated to protect the cell from free radical damage as it can decrease the level of “lipid peroxides” over time. There are other products combining Nrf2 stimulators as well.

3. RESTORE CELL ENERGY IN THE MITOCHONDRIA:

     A. Increase cell energy by increasing NAD+ in the cell with Nicotinamide Riboside: More NAD+ in the cell means not only more energy can be produced for your functioning, but also more energy for the cell to dispose of inefficient mitochondria and build smaller, more efficient mitochondria–Another way of contributing to mitochondrial mitophagy and biogenesis. 

     B. Increase cell energy by decreasing the activity of p38. Reducing this energy-expensive process allows more energy for these other repair processes. Interestingly, the food-derived flavanoid, apigenin, is a powerful inhibitor of CD38.  Treatment of cell cultures with apigenin increased NAD levels in the cells..

Reference: 2012 Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.

Here is a list of the foods with the highest concentration of apigenin:

Value Per Nutrient Food
13506.20 mg 100 grams Apigenin Spices, parsley, dried
302.00 mg 100 grams Apigenin Parsley, raw
8.71 mg 100 grams Apigenin Peppermint, fresh
5.00 mg 100 grams Apigenin Thyme, fresh
4.61 mg 100 grams Apigenin Celery, raw
3.85 mg 100 grams Apigenin Rutabagas, raw
2.41 mg 100 grams Apigenin Celeriac, raw

 

C. Increase Cell Energy by providing the supplements that improve the function of the mitochondria.

     A. Supplement with  CoEnzyme Q10, a necessary part of the heart of the mitochondria-the Electron Transport Chain bellow:

     B. Increase cell energy with any of the following other supplements which help the functioning of the mitochondria: Acetyl-L-Carnitine, Resveratrol, Membrane- Phospholipids, Creatine, Alpha-Lipoic Acid, Green Tea, Glucosamine, Omega-3-Fatty Acids, &             N-Acetyl-Cysteine 

Mitochondria Nutrients Great Pic

C. Improve Mitochondrial functioning by Reducing Mitochondrial Free Radicals (ROS & RNS) Damage:

     A. Take 3-5 mg of Melatonin at bedtime. As you see below, Melatonin has multiple beneficial effects on your mitochondrial functioning.

Mitochondria Melatonin

Melatonin permeates cell membranes and scavenges the ROS (“free radicals”) in the cell cytoplasm, mitochondria and nucleus. In the cytoplasm, melatonin maintains GSH homeostasis. Melatonin also regulates the expression of anti-oxidant enzymes, such as glutathione peroxidase (GPx), glutathione reductase (GRd) and superoxide dismutase (SOD), and downregulates pro-oxidant enzymes, such as the NOSs, particularly the iNOS. Melatonin is accumulated in mitochondria at high concentrations, where it scavenges ROS and RNS. Melatonin also protects cardiolipin from oxidation and prevents respiratory chain complexes, as well as mtDNA from free radical attack, thus ultimately protecting the membrane permeability transition (mPT) pore, thus preventing cell apoptosis.

     B. Carnisine 1.5-2.0 grams/day

Carnosine

     C. Supplement with Glutathione–The master protector 

See CFIDS: Increase Cell Energy


Take EXTRA Vitamin C and Pycnogenol to increase your free radical defense.


Learn to separate activities that produce large amounts of free radicals. For instance, separate eating from exercise by over one hour

Start your meal with healthy nutrients to promote Liver & GI function. See Detox Liver               

Finally,  See list below to choose high “ORAC” foods in your diet–graded by how well they neutralize the free radicals from a meal–Especially in high protein or high fat meals. Or use high ORAC supplements such as Optiberry or Purple defense.

Mild Cell Stress and Nutrients stimulate ARE

Rank Food Serving Size Total Antioxidant
Capacity per
serving size
1 Small Red Bean 1/2 cup
dried beans
13727
2 Wild blueberry 1 cup 13427
3 Red kidney bean 1/2 cup
dried beans
13259
4 Pinto bean 1/2 cup 11864
5 Blueberry 1 cup cult-
ivated berries
9019
6 Cranberry 1 cup
whole berries
8983
7 Artichoke hearts 1 cup
cooked
7904
8 Blackberry 1 cup 7701
9 Prune 1/2 cup 7291
10 Raspberry 1 cup 6058
11 Strawberry 1 cup 5938
12 Red Delicious apple 1 5900
13 Granny Smith 1 5381
14 Pecan 1 ounce 5095
15 Sweet cherry 1 cup 4873
16 Black plum 1 4844
17 Russet potato 1 cooked 4649
18 Black bean 1/2 cup
dried beans
4181
19 Plum 1 4118
20 Gala apple 1 3903

To give you an idea of how ORAC-powerful the spices can be, look at this 2006 list from

Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States

The 50 foods with the highest antioxidant content per 100 grams (< 4 ounces)

Product Antioxidant content1
mmol/100 g
Cloves, ground 125.549
Oregano leaf, dried 40.299
Ginger, ground 21.571
Cinnamon, ground 17.647
Turmeric powder 15.679
Walnuts 13.126
Basil leaf, dried 12.307
Mustard seed, yellow, ground 10.527
Curry powder 9.980
Pecans 9.668
Chocolate, baking, unsweetened 8.876
Paprika 8.601
Chili powder 8.372
Parsley, dried 7.430
Molasses, dark 4.900
Pepper, black 4.444
Artichokes, prepared 4.237
Chocolate, dark 4.188
Blackberries 3.990
Whole-grain cereal 3.412
Cranberries 3.289
Pudding mix, chocolate, cook-and-serve 3.026
Bran cereal 2.925
Power bar, chocolate flavor2 2.757
Chocolates, sugar-free 2.567
Raspberries 2.334
Strawberries 2.159
Blueberries 2.154
Cabbage, red, cooked 2.153
Wine, red 2.135
Barley malt syrup, organic 2.121
Prunes 2.018
Cherries, sour 1.814
Peppers, red, cooked 1.640
Chocolate cookies with vanilla creme filling 1.604
Cocoa Krispies cereal3 1.558
Chocolate chip cookies 1.524
Mustard, yellow, prepared 1.501
Milk-chocolate candy 1.483
Pistachios 1.426
Plums 1.330
Kiwi fruit 1.325
Corn flakes 1.255
Coffee 1.249
Spinach, frozen 1.226
Flaxseed, ground or milled 1.125
Rice and corn cereals 1.121
Toasty peanut crackers 1.101
Cupcakes, chocolate 1.059
Grape juice 1.011

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