Pathways to Health Through Supplementation

Overall Goal: Mildly stimulate the cell’s “antioxidant response element.”” (called the “Cellular stress response” below) to change gene production to protect cell health and help prevent aging.

Mild Cell Stress and Nutrients stimulate ARE

Nrf2 Stimulates the ARE (antioxidant response element): Protandim, Tumeric (same as Curcurmin), Cruciferous Vegetables, Enerolactones, Resveratrol, Wasabe:

Nrf2

Nrf2 detail

Stimulate SIRT 1: Fasting Caloric Restriction, Reseratrol

SIrt1

 

Stimulate AMPK: (co-operates with SIRT 1): Gynostemma Pentaphyllum Extact, Trans-tiliroside (in Rose Hips)–Both found in Lifesion’s  AMPK Activator, other nutrients, Exercise, Caloric Restriction, Resveratrol and Acetyl-L-Carnitine
SIrt1 and AMPK

It is important to activate cellular AMPK because in response to aging, excess calorie consumption, or low levels of physical activity, AMPK activity markedly declines.

Scientists uncovered the cell-energizing effect of AMPK in the 1970’s . Since then, over 7,500 published studies have documented the critical role that activated AMPK plays in maintaining life-sustaining cellular functions. (ref: Life Extension)

 

Decrease p38 and increase NAD+ in and out of the cell: More NAD+ is like having more energy, and it declines with aging:

p38

Unfortunately, CD38 is a very inefficient enzyme and consumes as many as 100 NADs for every one cyclic-ADP-ribose that it makes. For this reason, some experts on CD38 feel that the #1 function of CD38 is to regulate cellular NAD levels.

A strong argument for this theory is the recent discovery that CD38 is found inside the cell as well, bound to membranes on the inner portion of the cell nucleus. Here it could deplete nuclear NAD.

 Interestingly, the apple skin-derived flavanoid, apigenin, is a powerful inhibitor of CD38.  Treatment of cell cultures with apigenin increased NAD levels in the cells, reduced global acetylation of proteins, and reduced the acetylation of p53 and RelA-p65 subunits of NF-kB.

Reference: 2012 Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.

Here is a list of the foods with the most concentrations of apigenin:

Value Per Nutrient Food
13506.20 mg 100 grams Apigenin Spices, parsley, dried
302.00 mg 100 grams Apigenin Parsley, raw
8.71 mg 100 grams Apigenin Peppermint, fresh
5.00 mg 100 grams Apigenin Thyme, fresh
4.61 mg 100 grams Apigenin Celery, raw
3.85 mg 100 grams Apigenin Rutabagas, raw
2.41 mg 100 grams Apigenin Celeriac, raw

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